Clinical Phenotyping Core

Chronic kidney disease is associated with progressive disturbances in growth and maturation, bone accrual and quality, nutritional status, and cardiovascular health. A critical need exists for validated strategies to prevent and treat these complications, optimize growth and development, and improve long-term outcomes for this high-risk population. The Clinical Phenotyping Core leverages the resources of CHOP’s Clinical and Translational Research Center and state-of-the-art methods for assessing bone quality, body composition, bionutrition, and vascular health.

The goals of the Clinical Phenotyping Core are to provide expert consultation to investigators on clinical phenotyping protocols for observational studies and clinical trials in childhood kidney diseases; facilitate the implementation of clinical research through access to state-of-the-art and comprehensive core resources for assessment of growth and nutrition, body composition, bone quality, and cardiovascular health; and contribute to the expansion and generation of robust sources of normative longitudinal data for clinical phenotyping measures.

Core Services include:

  • Anthropometric growth assessment
  • Body composition
  • Whole body dual-energy x-ray absorptiometry (DXA)
  • Air displacement plethysmography
  • Multi-frequency bioelectrical impedance analysis (BIA)
  • Bone health assessment
  • DXA areal bone mineral density and content at multiple anatomic sites
  • Peripheral quantitative computed tomography (pQCT) measures of volumetric bone mineral density
  • Second generation high-resolution pQCT (XCTII) measures of bone microarchitecture and micro-finite element analysis estimates of bone strength (failure load) that are highly correlated with ex vivo biomechanical testing.
  • Micro-finite element analysis (μFEA)
  • Muscle strength measures
  • Dynamometry
  • Hand-grip dynamometry
  • Force plate jump mechanography
  • Cardiovascular profling
  • Pulse wave velocity/analysis
  • Carotid intima-media thickness
  • Endothelial peripheral arterial tone (EndoPAT)
  • Ambulatory blood pressure monitoring
  • Echocardiography
  • Dietary assessment
  • Food records
  • Dietary recalls
  • Study meals
  • Resting energy expenditure (REE)

Center for Human Phenomic Science at CHOP: Nutrition Core
Center for Human Phenomic Science at CHOP: Cardiovascular Core